Field notes from a decade inside hEDS, MCAS, and regenerative medicine.https://stemcell.news/https://stemcell.news/2025/07/27/inflammaging-and-exosomes/https://stemcell.news/2025/07/27/inflammaging-and-exosomes/Inflammaging is a driver of age-related disease, not just a symptom. Exosomes may help, but in a largely unregulated market the variability between batches — even from the same source tissue — makes caution non-optional.Sun, 27 Jul 2025 00:00:00 GMThttps://stemcell.news/2025/06/18/botox-safety-side-effects/https://stemcell.news/2025/06/18/botox-safety-side-effects/Fifteen years of ~20 units every 4–6 months, then I stopped — hip abduction nearly doubled from 90–100 lbs to 180 lbs and I pulled up unassisted for the first time. The Alzheimer's link is my working hypothesis, not established fact. The strength data is mine.Wed, 18 Jun 2025 00:00:00 GMThttps://stemcell.news/2025/04/28/stellate-ganglion-blocks-hoffman-process/https://stemcell.news/2025/04/28/stellate-ganglion-blocks-hoffman-process/Two upstream resets — Neuro-Reset with bilateral stellate blocks and vagus hydrodissection, and the Hoffman Process — that finally made the regenerative work stick after years of cycling back into flares.Mon, 28 Apr 2025 00:00:00 GMThttps://stemcell.news/2025/04/26/managing-heds-mcas-pots-dysautonomia/https://stemcell.news/2025/04/26/managing-heds-mcas-pots-dysautonomia/After seven years of trial, error, and rebuilding, these are the interventions that moved me from bedbound to functional: stellate ganglion blocks, environmental detox, slow tendon loading, osteopathic care paired with regenerative medicine, and a multi-year timeline.Sat, 26 Apr 2025 00:00:00 GMThttps://stemcell.news/2025/03/10/exosome-therapy-risks-and-side-effects/https://stemcell.news/2025/03/10/exosome-therapy-risks-and-side-effects/Three real cases of serious complications from IV exosome therapy — cancer recurrence, DVT, systemic inflammation — plus what I've learned about source verification, batch characterization, and why microneedling is a very different risk profile than IV.Mon, 10 Mar 2025 00:00:00 GMThttps://stemcell.news/2025/02/22/eds-picl-cci/https://stemcell.news/2025/02/22/eds-picl-cci/An evolving question in craniocervical instability: does anterior pannus rule out PICL? A real case, the conflicting reads, and what Henderson and Centeno actually say about it.Sat, 22 Feb 2025 00:00:00 GMThttps://stemcell.news/2025/02/15/heds-and-mcas/https://stemcell.news/2025/02/15/heds-and-mcas/A decade of trial and error compressed into a working protocol — diagnostics, injury sequencing, mast cell control, hormones, and the specific physicians who actually understand the overlap.Sat, 15 Feb 2025 00:00:00 GMThttps://stemcell.news/2025/02/10/lonnie-rae-ehlers-danlos-syndrome/https://stemcell.news/2025/02/10/lonnie-rae-ehlers-danlos-syndrome/The personal case study underneath every other post on this site — what hEDS and MCAS did to my body, what surgeries and regenerative work undid, and the specific genetic and biochemical levers that mattered.Mon, 10 Feb 2025 00:00:00 GMThttps://stemcell.news/2025/02/05/fda-stem-cell-exosome-therapy-warning-letters/https://stemcell.news/2025/02/05/fda-stem-cell-exosome-therapy-warning-letters/The FDA issued warning letters to Chara Biologics, INCELL, Neobiosis, and Platinum Biologics for cGMP violations and unapproved biologic manufacturing — reframing perinatal-derived products as biologic drugs rather than tissue allografts.Wed, 05 Feb 2025 00:00:00 GMThttps://stemcell.news/2025/02/05/muse-cell-therapy-explained/https://stemcell.news/2025/02/05/muse-cell-therapy-explained/My February 2025 take on Muse cells. I no longer hold this view — after a year reading the primary literature, my position has changed. The original post is preserved below, unedited.Wed, 05 Feb 2025 00:00:00 GMThttps://stemcell.news/2025/02/04/fda-warning-chara-biologics-unapproved-stem-cell-products/https://stemcell.news/2025/02/04/fda-warning-chara-biologics-unapproved-stem-cell-products/The FDA cited Chara Biologics for marketing three unapproved cell and exosome products — CharaExo, CharaCore, and CharaOmni — for conditions including Alzheimer's, Parkinson's, and autism. The agency flagged cGMP failures, misbranding, and unsupported clinical claims.Tue, 04 Feb 2025 00:00:00 GMThttps://stemcell.news/2025/02/04/microneedling-with-exosomes/https://stemcell.news/2025/02/04/microneedling-with-exosomes/Microneedling with exosomes can produce visibly better skin in a single session — when the exosomes are high-quality. The mechanism, the indications beyond skin, the risks of poorly processed product, and what to ask any provider.Tue, 04 Feb 2025 00:00:00 GMThttps://stemcell.news/2025/02/03/exosome-therapy/https://stemcell.news/2025/02/03/exosome-therapy/Exosomes are extracellular vesicles — signals, not cells — that may reduce inflammation and accelerate healing. They're also wrapped in marketing claims that don't hold up. What the science supports, what the FDA says, and what to ask any provider.Mon, 03 Feb 2025 00:00:00 GMThttps://stemcell.news/2025/02/01/exosome-vs-stem-cell-therapy/https://stemcell.news/2025/02/01/exosome-vs-stem-cell-therapy/Stem cells rebuild tissue; exosomes signal existing cells to do the work. The clinical, regulatory, and risk profiles are different enough that the choice matters. What I've learned from being a patient in both.Sat, 01 Feb 2025 00:00:00 GMThttps://stemcell.news/2025/01/22/the-ethics-of-stem-cell-therapy-navigating-controversies-and-advancements/https://stemcell.news/2025/01/22/the-ethics-of-stem-cell-therapy-navigating-controversies-and-advancements/What I had to learn the hard way about cell quality, expansion cycles, injector skill, and the insurance gap that funnels patients toward surgery — written for the patient who's been told regenerative medicine isn't real medicine.Wed, 22 Jan 2025 00:00:00 GMThttps://stemcell.news/2025/01/20/longevity-anti-aging-therapies/https://stemcell.news/2025/01/20/longevity-anti-aging-therapies/What I've learned working with Bodor, Paul, Cugat, Cook, Kuo, and Tamayo on the muscle-first view of aging — Emsculpt Neo, Emface, PRP, BMAC, exosomes, and why I stopped Botox and gained 80+ lbs of hip abduction strength.Mon, 20 Jan 2025 00:00:00 GMThttps://stemcell.news/2025/01/20/regenerative-medicine-orthopedic-treatments/https://stemcell.news/2025/01/20/regenerative-medicine-orthopedic-treatments/Stem cells, PRP, PRGF, and exosomes have a real role in orthopedic care — for the right indication, with the right operator, under the right regulatory framework. Here's where the evidence lands and what to ask before any injection.Mon, 20 Jan 2025 00:00:00 GMThttps://stemcell.news/2025/01/20/regenerative-medicine-sports-injury-recovery/https://stemcell.news/2025/01/20/regenerative-medicine-sports-injury-recovery/PRP, PRGF, BMAC, mFAT, donor MSCs, Wharton's jelly, exosomes — the regenerative toolkit for sports injuries is bigger than most athletes know. What each is good for, what each isn't, and where the regulatory lines sit.Mon, 20 Jan 2025 00:00:00 GMThttps://stemcell.news/2025/01/19/does-prp-work/https://stemcell.news/2025/01/19/does-prp-work/PRP, PRF, and PRGF helped me avoid a second spinal fusion and recover function across hips, knees, and feet. What the therapies actually do, why operator skill is the variable that matters, and what the FDA does and doesn't regulate.Sun, 19 Jan 2025 00:00:00 GMThttps://stemcell.news/2025/01/19/future-of-pain-management/https://stemcell.news/2025/01/19/future-of-pain-management/A daily pain level of 9 is now a 1–2. The combination that got me there: PRP and PRGF for structural repair, exosomes for inflammation, osteopathic care for alignment, and a small group of named physicians who actually understood the conditions.Sun, 19 Jan 2025 00:00:00 GMT